Publications

Scientific publication by Targetex:

Bereczki, I., Vimberg, V., Lőrincz, E., Papp, H., Nagy, L., Kéki, S., Batta, G., Mitrović, A., Kos, J., Zsigmond, Á., Hajdú, I., Lőrincz, Z., Bajusz, D., Petri, L., Hodek, J., Jakab, F., Keserű, G M., Weber, J., Naesens, L., Herczegh, P., Borbás, A. (2022)

Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria.

Sci. Rep. 2022 12(1), p.16001 IF = 4.379

https://www.nature.com/articles/s41598-022-20182-y

Stern N, Gacs A, Tátrai E, Flachner B, Hajdú I, Dobi K, Bágyi I, Dormán G, Lőrincz Z, Cseh S, Kígyós A, Tóvári J, Goldblum A. (2022)

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimerʼs Disease: From In Silico to In Vivo

Int. J. Mol. Sci. 2022 23(22), p.13908 IF = 6.208

https://www.mdpi.com/1422-0067/23/21/13098

Flachner B, Dobi K, Benedek A, Cseh S, Lőrincz Z, Hajdú I (2022)

Robust Recombinant Expression of Human Placental Ribonuclease Inhibitor in Insect Cells.

Biomolecules 2022 12(2), p.273 IF = 6.064

https://www.mdpi.com/2218-273X/12/2/273

Pape VF, Palkó R, Tóth S, Szabó MJ, Sessler J, Dormán G, Enyedy EA, Soós T, Szatmári I, Szakács G.(2022)

Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer.

J. Med. Chem. 2022 May 25. IF = 7.446

https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c00076

Bereczki I, Papp H, Kuczmog A, Madai M, Nagy V, Agócs A, Batta G, Milánkovits M, Ostorházi E, Mitrović A, Kos J, Zsigmond Á, Hajdú I, Lőrincz Z, Bajusz D, Keserű GM, Hodek J, Weber J, Jakab F, Herczegh P, Borbás A. (2021)

Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 Replication

Pharmaceuticals, 14(11), 1111. IF = 5.83

https://www.mdpi.com/1424-8247/14/11/1111

Szilágyi K, Flachner B, Hajdú I, Szaszkó M, Dobi K, Lőrincz Z, Cseh S, Dormán G. (2021)

Rapid Identification of Potential Drug Candidates from Multi-Million Compounds’ Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening.

Molecules. 26:E5593 IF: 4,41

https://www.mdpi.com/1420-3049/26/18/5593

Dormán G, Flachner B, Hajdú I, András C. (2021)

Target identification and polypharmacology of nutraceuticals.

In: Nutraceuticals: Efficacy, Safety and Toxicity (Ed. R. Gupta, A. Lall, R. Srivastava), Academic Press, pp. 315-343.

https://www.sciencedirect.com/science/article/pii/B9780128210383000239

Gömöri K, Szabados T, Kenyeres É, Pipis J, Földesi I, Siska A, Dormán G, Ferdinandy P, Görbe A, Bencsik P. (2020)

Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors.

Int. J. Mol. Sci. 21, 6990. IF=5.923

https://www.mdpi.com/1422-0067/21/19/6990

Szilágyi K, Hajdú I, Flachner B, Lőrincz Z, Balczer J, Gál P, Závodszky P, Pirli C, Balogh B, Mándity IM, Cseh S, Dormán G. (2019)

Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches.

Molecules. 24:E3641 IF: 3,267

https://www.mdpi.com/1420-3049/24/20/3641

Hajdú I, Kardos J, Major B, Fabó G, Lőrincz Z, Cseh S, Dormán G. (2018)

Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.

Bioorg Med Chem Lett. 28, 3113-3118. IF: 2,448

https://www.sciencedirect.com/science/article/pii/S0960894X18305535

Bencsik P, Kupai K, Görbe A, Kenyeres É, Varga ZV, Pálóczi J, Gáspár R, Kovács L, Weber L, Takács F, Hajdú I, Fabó G, Cseh S, Barna L, Csont T, Csonka C, Dormán G, Ferdinandy P. (2018)

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.

Front Pharmacol, 9,296 IF: 3,845

https://www.frontiersin.org/articles/10.3389/fphar.2018.00296/full

Szaszkó, M., Hajdú, I., Flachner, B., Dobi, K., Magyar, C., Simon, I., Lőrincz, Z., Kapui, Z., Pázmány, T., Cseh, S., Dormán, G. (2017)

Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening

Molecular Diversity, 21, 175-86. IF:2,229

https://link.springer.com/article/10.1007%2Fs11030-016-9717-4

Dormán G, Nakamura H, Pulsipher A, Prestwich GD. (2016)

The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore.

Chem Rev. 116, 15284-15398. IF:47,928

https://pubs.acs.org/doi/10.1021/acs.chemrev.6b00342

Kelemen ÁA, Kiss R, Ferenczy GG, Kovács L, Flachner B, Lőrincz Z, Keserű GM.

Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments. (2016)

J Chem Inf Model. 56, 412-22. IF: 3,760

https://pubs.acs.org/doi/10.1021/acs.jcim.5b00598

Dobi, K., Flachner, B., Pukáncsik, M., Máthé, E., Bognár, M., Szaszkõ, M., Magyar, C., Hajdú, I., Lorincz, Z., Simon, I., Fülöp, F., Cseh, S., Dormán, G. (2015)

Combination of Pharmacophore Matching, 2D Similarity Search, and in Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories

Chemical Biology and Drug Design, 86, 864-80. IF: 2,802

https://onlinelibrary.wiley.com/doi/full/10.1111/cbdd.12563

Dobi, K., Hajdú, I., Flachner, B., Fabó, G., Szaszkó, M., Bognár, M., Magyar, C., Simon, I., Szisz, D., Lõrincz, Z., Cseh, S., Dormán, G. (2014)

Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors

Molecules, 19, 7008-39. IF: 2,416

https://www.mdpi.com/1420-3049/19/6/7008

Hajdú, I., Flachner, B., Bognár, M., Végh, B.M., Dobi, K., Lorincz, Z., Lázár, J., Cseh, S., Takács, L., Kurucz, I. (2014)

Monoclonal antibody proteomics: Use of antibody mimotope displaying phages and the relevant synthetic peptides for mAb scouting

Immunology Letters, 160, 172-7. IF: 2,512

https://www.sciencedirect.com/science/article/pii/S0165247814000236

Flachner, B., Tömöri, T., Hajdú, I., Dobi, K., Lorincz, Z., Cseh, S., Dormán, G. (2014)

Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: Biological evaluation

Medicinal Chemistry Research, 23, 1234-47. IF: 1,402

https://link.springer.com/article/10.1007/s00044-013-0695-0

Flachner B, Lörincz Z, Carotti A, Nicolotti O, Kuchipudi P, Remez N, Sanz F, Tóvári J, Szabó MJ, Bertók B, Cseh S, Mestres J, Dormán G. (2012)

A chemocentric approach to the identification of cancer targets.

PLoS One. 7, e35582 IF:3,730

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035582

Tömöri T, Hajdú I, Barna L, Lőrincz Z, Cseh S and Dormán G (2012)

Combining 2D and 3D in silico methods for rapid selection of potential PDE5 inhibitors from multimillion compounds’ repositories: biological evaluation.

Mol Divers. 16, 59-72 IF: 2,861

https://link.springer.com/article/10.1007/s11030-011-9335-0

Berta J1, Kenessey I, Dobos J, Tovari J, Klepetko W, Jan Ankersmit H, Hegedus B, Renyi-Vamos F, Varga J, Lorincz Z, Paku S, Ostoros G, Rozsas A, Timar J, Dome B. (2010)

Apelin expression in human non-small cell lung cancer: role in angiogenesis and prognosis.

J Thorac Oncol. 5, 1120-9. IF: 4,040

https://www.sciencedirect.com/science/article/pii/S1556086415305694

Kenessey I, Keszthelyi M, Krámer Z, Berta J, Adám A, Dobos J, Mildner M, Flachner B, Cseh S, Barna G, Szokol B, Orfi L, Kéri G, Döme B, Klepetko W, Tímár J, Tóvári J. (2010)

Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma.

Curr Cancer Drug Targets 10, 332-42 IF:4,771

https://www.eurekaselect.com/69470/article

Kupai K, Szucs G, Cseh S, Hajdu I, Csonka C, Csont T and Ferdinandy P (2010)

Matrix metalloproteinase activity assays: Importance of zymography.

J Pharmacol Toxicol Methods 61, 205-9

https://www.sciencedirect.com/science/article/pii/S1056871910000274

Dormán G, Cseh S, Hajdú I, Barna L, Kónya D, Kupai K, Kovács L and Ferdinandy P (2010)

Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility

Drugs 70, 949-64 IF: 3,738

https://link.springer.com/article/10.2165/11318390-000000000-00000

Vass L1, Kelemen JZ, Fehér LZ, Lorincz Z, Kulin S, Cseh S, Dormán G, Puskás LG. (2009)

Toxicogenomics screening of small molecules using high-density, nanocapillary real-time PCR.